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Tissue plasminogen activator‐mediated PDGF signaling and neurovascular coupling in stroke
Author(s) -
SU E. J.,
FREDRIKSSON L.,
SCHIELKE G.P.,
ERIKSSON U.,
LAWRENCE D.A.
Publication year - 2009
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2009.03402.x
Subject(s) - neurovascular bundle , tissue plasminogen activator , stroke (engine) , medicine , ischemic stroke , activator (genetics) , plasminogen activator , thrombolysis , neuroscience , ischemia , cardiology , bioinformatics , pharmacology , surgery , biology , receptor , mechanical engineering , engineering , myocardial infarction
Summary. The use of tissue plasminogen activator (tPA) as a thrombolytic treatment in ischemic stroke is limited largely due to concerns for hemorrhagic complications. The underlying mechanisms are still unknown, but evidence is beginning to emerge that tPA interacts with key regulators of the neurovascular unit (NVU), and that these interactions may contribute to the undesirable side effects associated with the use of tPA in ischemic stroke. Understanding these connections and tPA’s normal function within the NVU may offer new insights into future therapeutic approaches.