Premium
Dynamics of platelet thrombus formation
Author(s) -
JACKSON S. P.,
NESBITT W. S.,
WESTEIN E.
Publication year - 2009
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2009.03401.x
Subject(s) - thrombus , platelet , chemistry , mechanotransduction , platelet adhesiveness , integrin , platelet activation , agonist , biophysics , microbiology and biotechnology , platelet aggregation , receptor , medicine , biochemistry , biology
Summary. Platelet aggregation and thrombus formation at sites of atherosclerotic plaque rupture is a dynamic process that can lead to intermittent or permanent obstruction to blood flow, resulting in ischemic tissue injury and organ dysfunction. There is a growing body of evidence suggesting that the dynamics of platelet aggregation and initial thrombus development are regulated by two distinct, complementary processes, involving: (i) rheological (biomechanical) and (ii) soluble‐agonist ‐dependent mechanisms. Rheological‐dependent platelet aggregation occurs between discoid platelets and requires the biomechanical adhesive and signaling function (mechanotransduction) of the major platelet adhesion receptors, GPIb and integrin α IIb β 3 . Soluble agonists further potentiate platelet activation, stimulating global platelet shape change and degranulation, and play a major role in stabilizing formed aggregates. Unraveling the dynamics of platelet aggregation and thrombus formation in vivo requires consideration of the cooperative interplay between rheological‐ and soluble agonist‐dependent platelet aggregation mechanisms.