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Genetics of venous thrombosis
Author(s) -
ROSENDAAL F. R.,
REITSMA P. H.
Publication year - 2009
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2009.03394.x
Subject(s) - fibrinogen , antithrombin , thrombosis , pulmonary embolism , factor v leiden , deep vein , venous thrombosis , risk factor , protein c , medicine , factor v , gastroenterology , cardiology , heparin
Summary. Venous thrombosis (deep vein thrombosis, pulmonary embolism) is a common and serious disorder, with genetic and acquired risk factors. The genetic risk factors can be subdivided in to those that are strong, moderate and weak. Strong risk factors are deficiencies of antithrombin, protein C and protein S. Moderately strong are factor V Leiden, prothrombin 20210A, non‐O blood group and fibrinogen 10034T. There are many weak genetic risk factors, including fibrinogen, factor XIII and factor XI variants. Even for moderately strong risk factors (relative risks 2–5), the majority of carriers will never develop thrombosis.