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Duration of anticoagulation after initial idiopathic venous thrombosis – the swinging pendulum: Risk assessment to predict recurrence
Author(s) -
EICHINGER S.,
KYRLE P. A.
Publication year - 2009
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2009.03383.x
Subject(s) - medicine , thrombophilia , risk assessment , venous thrombosis , intensive care medicine , thrombosis , risk stratification , risk factor , computer science , computer security
Summary. Despite considerable advances in the identification of new risk factors for VTE, predicting the risk of recurrence in an individual patient remains a challenge. The impact of many of these risk factors on the recurrence risk is moderate, while the relevance of others is unknown or is regarded controversial. The determination of some markers of thrombophilia either lacks standardization or is too elaborate for routine purposes. Many patients carry more than one risk factor and their combined effect is unknown. Use of global coagulation markers that encompass the effects of clotting and/or fibrinolytic defects may improve risk assessment. In a future step, prothrombotic coagulation alterations need to be integrated with clinical risk factors. Reproducible and simple scoring systems may improve stratification of patients according to their recurrence risk and optimize duration of anticoagulant therapy.