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Novel molecules in calcium signaling in platelets
Author(s) -
BERGMEIER W.,
STEFANINI L.
Publication year - 2009
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2009.03379.x
Subject(s) - platelet , calcium , chemistry , calcium signaling , microbiology and biotechnology , cell signaling , signal transduction , biochemistry , medicine , biology , organic chemistry
Summary. A rise in the intracellular calcium (Ca 2+ ) concentration is a major component of the signaling mechanisms regulating platelet function in thrombosis and hemostasis. Previous studies, however, failed to identify many key molecules regulating Ca 2+ signaling in platelets. Here, we review recent findings, which identified CalDAG‐GEFI as a critical Ca 2+ sensor that links increases in intracellular Ca 2+ to integrin activation, TxA 2 formation, and granule release in stimulated platelets. Furthermore, we summarize work that lead to the discovery of STIM1 and Orai1 as key regulators of store‐operated calcium entry (SOCE) in platelets. A short discussion on the usefulness of each molecule as a potential new target for antiplatelet therapy is included.