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The role of the intrinsic apoptosis pathway in platelet life and death
Author(s) -
KILE B. T.
Publication year - 2009
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2009.03366.x
Subject(s) - microbiology and biotechnology , apoptosis , programmed cell death , biology , proteases , caspase , intrinsic apoptosis , signal transduction , platelet , xiap , immunology , genetics , biochemistry , enzyme
Summary. In recent years, it has become increasingly apparent that the production of platelets and their subsequent life span in the circulation are regulated, at least in part, by apoptotic mechanisms. There is also evidence implicating the apoptotic machinery in the regulation of platelet functional responses. This review examines the role of the intrinsic apoptosis pathway, regulated by the Bcl‐2 family of proteins, in platelet biology.