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Evidence that high von Willebrand factor and low ADAMTS‐13 levels independently increase the risk of a non‐fatal heart attack
Author(s) -
CRAWLEY J. T. B.,
LANE D. A.,
WOODWARD M.,
RUMLEY A.,
LOWE G. D. O.
Publication year - 2008
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2008.02902.x
Subject(s) - adamts , von willebrand factor , thrombospondin , medicine , body mass index , risk factor , adamts13 , myocardial infarction , fibrinogen , metalloproteinase , endocrinology , matrix metalloproteinase , platelet
Summary. Background: A disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS‐13) may influence von Willebrand factor (VWF) levels and consequently the risk of myocardial infarction (MI). Moreover, ADAMTS‐13 influences hemostatic plug formation in mouse models. We therefore studied their associations in the Glasgow MI Study (GLAMIS). Methods and results: We measured ADAMTS‐13 and VWF antigen levels by ELISAs in stored plasma from a case–control study of 466 MI cases and 484 age‐ and sex‐matched controls from the same north Glasgow population. There was no correlation between ADAMTS‐13 and VWF levels in cases or controls. ADAMTS‐13 levels correlated positively with serum cholesterol and triglycerides and body mass index, and negatively with high‐density lipoprotein‐cholesterol. VWF levels correlated with age, fibrinogen and C‐reactive protein. In multivariable analyses including risk factors, VWF correlated positively with risk of MI, and ADAMTS‐13 correlated negatively with risk of MI. These associations were independent of each other. The association of ADAMTS‐13 with risk of MI was observed only in multivariable analysis. Conclusions: VWF and ADAMTS‐13 levels were not associated in this study, and showed associations with MI risk in opposite directions but of similar strength. The association of ADAMTS‐13 with MI is influenced by lipid levels, and consequently requires further investigation.