Premium
Coated‐platelets in ischemic stroke: differences between lacunar and cortical stroke
Author(s) -
PRODAN C. I.,
JOSEPH P. M.,
VINCENT A. S.,
DALE G. L.
Publication year - 2008
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2008.02890.x
Subject(s) - platelet , lacunar stroke , medicine , stroke (engine) , ischemic stroke , cardiology , pathological , brain ischemia , ischemia , mechanical engineering , engineering
Summary. Background: Coated‐platelets are a subset of platelets with procoagulant potential observed upon dual agonist stimulation with collagen and thrombin. Objective: The goal was to investigate if coated‐platelet production differs between patients with lacunar ischemic stroke and non‐lacunar (cortical) ischemic stroke as compared with controls. Patients and methods: Blood samples from 60 patients with ischemic stroke (20 lacunar and 40 cortical) and 70 controls were analyzed for coated‐platelet production. Results: Coated‐platelet production was significantly lower in patients with lacunar stroke (21.8 ± 11.4%, mean ± 1 SD) as compared with either controls (31.6 ± 13.2%, P = 0.008) or patients with cortical stroke (39.4 ± 12.7%, P < 0.001). The increase in coated‐platelets for patients with cortical stroke as compared with controls was also significant ( P = 0.008). Conclusions: Our results indicate a marked difference in coated‐platelet synthesis in lacunar vs. non‐lacunar stroke, thereby providing additional support for the existence of distinct pathological processes underlying these two subtypes of ischemic stroke. Further investigation of the role of coated‐platelets in stroke, taking into account these preliminary findings, is warranted.