Premium
ABO blood group, other risk factors and incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE)
Author(s) -
OHIRA T.,
CUSHMAN M.,
TSAI M. Y.,
ZHANG Y.,
HECKBERT S. R.,
ZAKAI N. A.,
ROSAMOND W. D.,
FOLSOM A. R.
Publication year - 2007
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2007.02579.x
Subject(s) - medicine , abo blood group system , odds ratio , risk factor , blood type (non human) , incidence (geometry) , case control study , body mass index , etiology , factor v leiden , gastroenterology , thrombosis , venous thrombosis , physics , optics
Summary. Background: Numerous case–control studies have reported higher prevalence of non‐O blood type among venous thromboembolism (VTE) patients than controls, but potential mechanisms or effect modifiers for the association are not fully established. Patients/methods: Using a nested case–control design combining the Atherosclerosis Risk in Communities and the Cardiovascular Health Study cohort, ABO blood type and other VTE risk factors were measured on pre‐event blood samples of 492 participants who subsequently developed VTE and 1008 participants who remained free of VTE. Results: A total of 64.4% of cases and 52.5% of controls had non‐O blood type. Among controls, mean values of factor VIIIc (FVIIIc) and von Willebrand factor among the non‐O blood type group were higher than among the O group. Compared with O blood type, the age‐adjusted odds ratio (OR) of VTE for non‐O blood type was 1.64 (95% CI, 1.32–2.05) and was similar for the two parent studies and race groups. Further adjustment for sex, race, body mass index, diabetes mellitus and FVIIIc reduced the OR: 1.31 (95% CI, 1.02–1.68). Factor V Leiden (FV Leiden) appeared to modify the non‐O blood type association with VTE in a supra‐additive fashion, with an age‐, sex‐ and race‐adjusted OR of 6.77 (95% CI, 3.65–12.6) for having both risk factors. Conclusions: Non‐O blood type was independently associated with risk of VTE, and added to the risk associated with FV Leiden.