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Platelets, inflammation and atherosclerosis
Author(s) -
LINDEMANN S.,
KRÄMER B.,
SEIZER P.,
GAWAZ M.
Publication year - 2007
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2007.02517.x
Subject(s) - platelet , inflammation , progenitor cell , microbiology and biotechnology , monocyte , foam cell , cell , immunology , endothelial stem cell , chemistry , macrophage , medicine , biology , stem cell , biochemistry , in vitro
Summary. An expanding body of evidence continues to build on the role of platelets as initial actors in the development of atherosclerotic lesions. Platelets bind to leukocytes and endothelial cells, and initiate monocyte transformation into macrophages. Platelets internalize oxidized phospholipids and promote foam cell formation. Platelets also recruit progenitor cells to the scene that are able to differentiate into foam cells or endothelial cells depending on conditions. Platelets tip the scales in the initiation, development and total extent of atherosclerotic lesions.