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The tissue factor–factor VIIa complex: procoagulant activity, regulation, and multitasking
Author(s) -
MONROE D. M.,
KEY N. S.
Publication year - 2007
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2007.02435.x
Subject(s) - tissue factor , hemostasis , factor viia , factor vii , human multitasking , inflammation , thrombosis , tissue factor pathway inhibitor , medicine , coagulation , bioinformatics , microbiology and biotechnology , immunology , biology , neuroscience
Summary. Greater understanding of the cellular interactions associated with tissue factor (TF), activated factor (F) VII and TF–FVIIa complexes is likely to provide considerable clinical benefit. This article reviews current knowledge on the function and regulation of TF and its role in a range of biological processes, including hemostasis, thrombosis and inflammation.