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A guide to murine fibrinolytic factor structure, function, assays, and genetic alterations
Author(s) -
MATSUO O.,
LIJNEN H. R.,
UESHIMA S.,
KOJIMA S.,
SMYTH S. S.
Publication year - 2007
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2007.02409.x
Subject(s) - fibrinolysis , function (biology) , adaptability , biology , computational biology , immunology , medicine , microbiology and biotechnology , ecology
Summary. The components and functions of the murine fibrinolytic system are quite similar to those of humans. Because of these similarities and the adaptability of mice to genetic manipulation, murine fibrinolysis has been studied extensively. These studies have yielded important information regarding the function of the several components of fibrinolysis. This review presents information on the structure, function and assay of mouse fibrinolytic parameters and it discusses the results of the extensive studies of genetically modified mice. It is intended to be a convenient reference resource for investigators of fibrinolysis.