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Tissue factor serum levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC‐Norfolk prospective population study
Author(s) -
KELLER T. T.,
NAGEL C.,
TE VELTHUIS H.,
GERDES V. E. A.,
WAREHAM N. J.,
BINGHAM S. A.,
LUBEN R.,
HACK C. E.,
REITSMA P. H.,
LEVI M.,
KHAW K. T.,
BOEKHOLDT S. M.
Publication year - 2006
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2006.02190.x
Subject(s) - epic , medicine , coronary artery disease , risk factor , prospective cohort study , population , environmental health , art , literature
Summary. Introduction: Tissue factor (TF) has been implicated in coronary artery disease (CAD). High levels of circulating TF are found in patients with acute atherothrombotic events. Whether high serum TF levels predict risk of future CAD independent of known risk factors remains unknown. Methods: We conducted a prospective case–control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC)‐Norfolk population study. Cases ( n = 1037) were apparently healthy men and women, aged 45–79 years, who developed fatal or non‐fatal CAD during follow‐up. Controls ( n = 2005) were matched by age, sex, and enrolment time. Serum TF levels were measured using high‐affinity antibodies. Results: In men, median TF levels were not significant higher in cases than in controls (59.0 pg mL −1 , range: 16.7–370.4 vs. 54.9 pg mL −1 , range: 16.2–452.4). In women, median TF levels were not significant higher in controls than in cases (73.4 pg mL −1 , range: 16.7–492.3 vs. 50.5 pg mL −1 , range: 16.5–376.7). The incidence of smoking was about double in the lowest compared with the highest TF quartile. Correcting for sex, age, body mass index, smoking, diabetes, systolic blood pressure, low‐density lipoprotein‐cholesterol, high‐density lipoprotein‐cholesterol and C‐reactive protein levels, the risk of future CAD was 1.05 (95% CI: 0.81–1.36) for people in the highest TF quartile, compared with those in the lowest ( P ‐value for linearity = 0.8). Conclusion: High levels of serum TF were not independently associated with an increased risk of future CAD in apparently healthy individuals.