Premium
Adrenal gland‐dependent augmentation of plasminogen activator inhibitor‐1 expression in streptozotocin‐induced diabetic mice
Author(s) -
OISHI K.,
OHKURA N.,
ISHIDA N.
Publication year - 2006
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2006.01980.x
Subject(s) - medicine , plasminogen activator inhibitor 1 , endocrinology , streptozotocin , diabetes mellitus , plasminogen activator , glucocorticoid , glucocorticoid receptor , adrenal gland
Summary. Background: Diabetes is associated with an excess risk of cardiac events, and one risk factor for infarction is an elevated level of plasminogen activator inhibitor‐1 (PAI‐1). Objectives and methods: To evaluate whether the glucocorticoid hormones are involved in the diabetes‐induced PAI‐1 production, we examined expression profiles of PAI‐1 mRNA in adrenalectomized (ADX) mice with streptozotocin (STZ)‐induced diabetes. Results: The diabetes‐induced augmentation of plasma PAI‐1 levels and PAI‐1 mRNA expression in the heart and lungs was completely normalized in diabetic ADX mice. The glucocorticoid receptor antagonist RU486 significantly, but only partly suppressed PAI‐1 induction in STZ‐induced diabetic mice, suggesting that factors other than glucocorticoids are also involved in PAI‐1 induction provoked by diabetes. Conclusion: Our results suggested that the adrenal gland plays a critical role in the progression of thrombosis in diabetic patients by inducing expression of the PAI‐1 gene.