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Soluble intracellular adhesion molecule‐1 is associated with cardiovascular disease risk and mortality in older adults
Author(s) -
JENNY N. S.,
ARNOLD A. M.,
KULLER L. H.,
SHARRETT A. R.,
FRIED L. P.,
PSATY B. M.,
TRACY R. P.
Publication year - 2006
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2005.01678.x
Subject(s) - medicine , hazard ratio , myocardial infarction , subclinical infection , proportional hazards model , endothelial activation , disease , cause of death , stroke (engine) , angina , endothelial dysfunction , cardiology , confidence interval , endothelium , mechanical engineering , engineering
Summary. Background: Intracellular adhesion molecule‐1 (ICAM‐1) regulates leukocyte‐endothelial attachment, a process crucial to atherosclerosis. Circulating soluble ICAM‐1 (sICAM‐1) may serve as a marker of cardiovascular disease (CVD) progression. Objectives: We examined the association of sICAM‐1 with measures of subclinical CVD and risk of incident CVD events and death in older men and women (age ≥65 years) from the Cardiovascular Health Study. Methods: Selected participants were free of clinical CVD at baseline. Non‐exclusive incident case groups were angina ( n = 534), myocardial infarction ( n = 304), stroke ( n = 327), and death ( n = 842; CVD death = 310). A total 643 subjects were free of events during follow‐up. Results: sICAM‐1 was positively associated with C‐reactive protein, interleukin‐6 and fibrinogen and measures of subclinical CVD in these older men and women. In Cox regression models adjusted for age, gender, and race, increasing levels of sICAM‐1 were associated with increased risk of all cause mortality in men and women. Hazard ratios (95% confidence intervals) for a one standard deviation increase in sICAM‐1 (89.7 ng mL −1 ) were 1.3 (1.1–1.4) in men and 1.2 (1.1–1.3) in women. sICAM‐1 was associated with increased risk of CVD death in women (1.2; 1.0–1.5), but not men (1.1; 0.9–1.3). There were no associations of sICAM‐1 with non‐fatal CVD events. Conclusions: While sICAM‐1 was associated with death in older men and women, there was a more marked association between sICAM‐1 and CVD death in women.