Premium
Stromelysin‐1 promoter 5A/6A polymorphism is an independent genetic prognostic risk factor and interacts with smoking cessation after index premature myocardial infarction
Author(s) -
LIU P.Y.,
LI Y.H.,
TSAI W.C.,
TSAI L.M.,
CHAO T.H.,
WU H.L.,
CHEN J.H.
Publication year - 2005
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2005.01515.x
Subject(s) - medicine , myocardial infarction , hazard ratio , smoking cessation , allele , risk factor , gene polymorphism , gastroenterology , confidence interval , gene , genetics , pathology , biology
Summary. Objective: To evaluate the prognostic roles of multiple polymorphisms and smoking cessation for premature myocardial infarction (MI). Methods: We studied 170 patients with MI onset before the age of 45 years (range 27–45 years, 84% men) and analyzed the traditional risk factors and several candidate genes’ associations with their subsequent coronary events. Results: Follow‐up data were available for a total of 162 individuals (95.3%) with the other 38 individuals (4.7%) being lost‐to‐follow‐up premature MI patients. During a mean period of 4.43 years’ follow‐up, diabetes mellitus (DM), hypertension, hypercholesterolemia and Killip's status ≥II were more frequent among patients with subsequent cardiac events (all P ‐values <0.05). The frequency of 5A allele of stromelysin‐1 gene was significantly higher among event group ( P = 0.01). Smoking cessation after MI, use of β ‐blocker or angiotensin‐converting enzyme inhibitor (ACEI) could improve outcome (all P ‐values <0.05). After multivariate analysis, we found that DM was an independent risk factor for survival [Hazard ratio (HR) 2.45, P = 0.01]. Successful smoking cessation and therapy with ACEI could have a protective effect (HR 0.33 and 0.09, P = 0.01 and <0.01, respectively). The stromelysin‐1 5A gene polymorphism was also an independent survival predictor (HR 2.51, P = 0.03). In addition, smoking cessation could significantly modify the risk, especially among patients with 5A allele polymorphism (HR 6.75 vs. 1.50). Conclusion: We thus conclude that the stromelysin‐1 gene polymorphism alone or in combination with smoking cessation can influence the prognosis after index premature MI.