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Factor XIII (FXIII) and angiogenesis
Author(s) -
DARDIK R.,
LOSCALZO J.,
INBAL A.
Publication year - 2006
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2005.01473.x
Subject(s) - angiogenesis , factor xiii , cancer research , medicine , fibrinogen
Summary. Factor XIII is a plasma transglutaminase that participates in the final stage of the coagulation cascade. Thrombin‐activated FXIII (FXIIIa) catalyzes the formation of covalent cross‐links between γ ‐glutamyl and ɛ ‐lysyl residues on adjacent fibrin chains in polymerized fibrin to yield the mature clot. In addition to its role in hemostasis, FXIII is known to participate in wound healing and embryo implantation, which are processes involving angiogenesis. In this review, we discuss the role of FXIII in angiogenesis and the molecular mechanisms underlying its proangiogenic effects. The FXIII role in tissue repair and remodeling may at least in part be attributed to its pro‐angiogenic activity.