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Platelet GPIb‐IX‐V‐dependent signaling
Author(s) -
OZAKI Y.,
ASAZUMA N.,
SUZUKIINOUE K.,
BERNDT M.C.
Publication year - 2005
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2005.01379.x
Subject(s) - signal transduction , phosphorylation , microbiology and biotechnology , tyrosine phosphorylation , proto oncogene tyrosine protein kinase src , phospholipase c , platelet activation , bruton's tyrosine kinase , chemistry , kinase , tyrosine kinase , biology , platelet , immunology
Summary. Although the signaling pathways related to GPIb‐IX‐V have not been fully elucidated, an accumulating body of evidence suggests that phospholipase C (PLC) γ 2 activation, subsequent Ca ++ release and oscillations constitute an essential signal transduction pathway related to GPIb‐IX‐V. Src family kinases are required for PLC γ 2 activation, while FcR γ ‐chain/Fc γ RIIA may be dispensable for PLC γ 2 activation. Although PI‐3K serves to potentiate various signaling events culminating in α IIb β 3 activation, PI‐3K activity may be dispensable for Src‐PLC γ 2 activation in GPIb‐IX‐V‐mediated signaling. Glycosphingolipid‐enriched microdomains (GEMs) appear to provide platforms for the signal transduction pathway related to GIb‐IX‐V, as the interaction between GPIb‐IX‐V and Src or PLC γ 2 tyrosine phosphorylation occurs exclusively in GEMs.