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HR2 haplotype in Arab population and patients with venous thrombosis in Kuwait
Author(s) -
JADAON M. M.,
DASHTI A. A.R
Publication year - 2005
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2005.01326.x
Subject(s) - medicine , haplotype , polymorphism (computer science) , gastroenterology , thrombosis , hemostasis , ethnic origin , ethnic group , venous thrombosis , population , risk factor , genotype , genetics , gene , biology , anthropology , environmental health , sociology
Summary. Background: Venous thromboembolism (VTE) occurs due to a number of hereditary and acquired disorders of hemostasis. A recently identified polymorphism in factor V gene (A4070G; named HR2) has been reported to be a possible risk factor for the development of VTE, with a high prevalence of 9.5%–15.2% in patients of different ethnic groups in different parts of the world. However, the prevalence of HR2 has not yet been tested in VTE patients of Arab ethnicity. Objectives: To study the prevalence and possible risk of HR2 haplotype in Arabs. Patients/methods: Exactly 188 VTE patients and 100 healthy subjects, all being of Arab ethnicity, were examined for HR2 using Polymerase chain reaction, restriction fragment length polymorphism and agarose gel electrophoresis. Results: Data showed that 31 patients and seven healthy subjects had HR2 haplotype, with a prevalence of 16.5% and 7%, respectively. Furthermore, 43 patients (22.9%) had more than one risk factor for VTE. Conclusions: The prevalence of HR2 in Arabs is quite high, with a 2.62‐fold greater risk of developing VTE. Moreover, coexistence of two or more genetic/acquired defects of VTE is quite common in Arab patients.