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REVIEW ARTICLE: Coated‐platelets: an emerging component of the procoagulant response
Author(s) -
DALE G. L.
Publication year - 2005
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2005.01274.x
Subject(s) - platelet , thrombospondin , prothrombinase , thrombin , chemistry , phosphatidylserine , von willebrand factor , fibrinogen , platelet activation , microbiology and biotechnology , serotonin , biophysics , biochemistry , receptor , immunology , biology , phospholipid , metalloproteinase , enzyme , membrane
Summary. Coated‐platelets, formerly known as COAT‐platelets, represent a subpopulation of cells observed after dual agonist stimulation of platelets with collagen and thrombin. This class of platelets retains on its surface high levels of several procoagulant proteins, including fibrinogen, von Willebrand factor, fibronectin, factor V and thrombospondin. Coated‐platelets also express surface phosphatidylserine and strongly support prothrombinase activity. Retention of α‐granule proteins on the surface of coated‐platelets involves an unexpected derivatization of these proteins with serotonin and an interaction of serotonin‐conjugated proteins with serotonin binding sites on fibrinogen and thrombospondin. This review will also detail experimental systems where coated‐platelets are generated as a result of other agonist(s). Finally, the putative physiological consequences of coated‐platelet formation will be discussed.