Premium
The angiotensin‐converting enzyme gene insertion/deletion polymorphism: insufficient evidence for a role in deep venous thrombosis
Author(s) -
BUDDINGH E. P.,
VAN HYLCKAMA VLIEG A.,
ROSENDAAL F. R.
Publication year - 2005
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2005.01129.x
Subject(s) - angiotensin converting enzyme , genotype , medicine , angiotensin ii , endocrinology , fibrinolysis , genetics , renin–angiotensin system , antithrombotic , gene , biology , microbiology and biotechnology , blood pressure
II: 0.7, 95% CI 0.5–1.0). When the subjects were stratified by sex, it became clear that the low overall risk for the D allele was due almost entirely to a reduced risk in women (DD vs. II women OR: 0.5, 95% CI: 0.3–0.9; men OR: 0.9, 95% CI 0.5–1.6). In men, no protective effect of the D-allele was found regardless of age, but the overall protective effect in women in our study was found to be restricted to women younger than 50 years of age (DD vs. II women 50 years OR: 1.1, 95% CI: 0.4–2.7). Adjustment for age and several other possible thrombophilic traits (use of an oral contraceptive, pre/postmenopausal status) did not affect these results.