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Negative impact of depression on outcomes in patients with coronary artery disease: mechanisms, treatment considerations, and future directions
Author(s) -
SHIMBO D.,
DAVIDSON K. W.,
HAAS D. C.,
FUSTER V.,
BADIMON J. J.
Publication year - 2005
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2004.01084.x
Subject(s) - coronary artery disease , depression (economics) , medicine , disease , antidepressant , cardiology , clinical trial , intensive care medicine , economics , macroeconomics , hippocampus
Summary. Depressive symptoms are common in coronary artery disease (CAD) patients, and are associated with increased cardiac risk. Although an important relation exists between depression and CAD prognosis, the underlying pathophysiological mechanisms are poorly understood. Additionally, evidence including the recently published ENRICHD (Enhancing Recovery in Coronary Heart Disease Patients) trial suggests that depression treatments do not lower recurrent cardiac risk. The reason for the observed lack of benefit with depression treatment in CAD patients is unclear. In this review, we discuss the impact of depression in CAD patients, the possible mechanisms involved, the studies that have examined the effects of psychological and antidepressant therapies on recurrent cardiac events, and the direction that future research should take.