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Elevated levels of FVIII:C within families are associated with an increased risk for venous and arterial thrombosis
Author(s) -
Bank I.,
Libourel E. J.,
Middeldorp S.,
Hamulyák K.,
Van Pampus E. C. M.,
Koopman M. M. W.,
Prins M. H.,
Van Der Meer J.,
Büller H. R.
Publication year - 2005
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2004.01033.x
Subject(s) - medicine , incidence (geometry) , thrombosis , myocardial infarction , odds ratio , venous thrombosis , coagulation , gastroenterology , risk factor , first degree relatives , cardiology , family history , optics , physics
Summary. Elevated levels of coagulation factor VIII:C (FVIII:C) are associated with an increased risk for venous and arterial thromboembolism. Whether relatives of patients with elevated levels of FVIII:C are also at increased risk for thrombotic disease is unknown. The objective was to determine the annual incidences of both venous and arterial thrombotic events in first‐degree relatives of patients with elevated levels of FVIII:C and venous thromboembolism (VTE) or premature atherosclerosis. A retrospective study with 584 first‐degree relatives of 177 patients with elevated levels of FVIII:C was performed. The level of FVIII:C was determined and relatives with elevated and normal levels of FVIII:C were compared. Of the participants, 40% had elevated levels of FVIII:C. The annual incidence of a first episode of VTE was 0.34% and 0.13% in relatives with elevated levels of FVIII:C and those with normal levels, respectively [OR 3.7 (95% CI 1.9–7.5)]. The absolute annual incidence in the youngest age group with elevated levels of FVIII:C was 0.16% (0.05–0.37) and gradually increased to 0.99% (0.40–2.04) in those older than 60 years of age, although the odds ratios were not statistically significant. The annual incidences of a first arterial thrombotic event were 0.29% and 0.14% in relatives with and without elevated levels of FVIII:C, respectively [OR 3.1 (1.4–6.6)]. In particular the risks for a first myocardial infarction [OR 4.3 (1.0–18.1); P =0.046] and a first peripheral arterial thrombosis [OR 8.6 (1.6–47.6)] were increased. Within families of patients with elevated levels of FVIII:C and VTE or premature atherosclerosis, 40% of their first‐degree relatives has elevated levels of FVIII:C as well, and they are at increased risk for both VTE and arterial thrombosis as compared with their relatives with normal levels.