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Comparison of transfusion efficacy of amotosalen‐based pathogen‐reduced platelet components and gamma‐irradiated platelet components
Author(s) -
Sigle JoergPeter,
Infanti Laura,
Studt JanDirk,
Martinez Maria,
Stern Martin,
Gratwohl Alois,
Passweg Jakob,
Tichelli André,
Buser Andreas S.
Publication year - 2013
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2012.03959.x
Subject(s) - apheresis , platelet , plateletpheresis , medicine , platelet transfusion , surgery
Background Trials of transfusions of platelets ( PLTs ) treated with amotosalen‐based pathogen reduction ( PR ) showed lower corrected count increments ( CCIs ) compared to conventional PLT components ( PCs ). However, PR‐PLTs and conventional PCs often differed in various factors besides PR . We compared transfusion efficacy of single‐donor apheresis PCs treated with PR or gamma irradiation. Study Design and Methods Hematologic patients were assigned to receive PR‐PLTs or gamma‐irradiated conventional PCs , both prepared in PLT additive solution ( PAS ). One‐hour CCI (primary endpoint), 24‐hour CCI , time to next PLT transfusion, and transfusion requirement of red blood cells and plasma were analyzed. Results Forty‐four patients assigned to PR‐PLTs received 220 PR‐PLTs and 136 conventional PCs ; 72 controls received 517 conventional PCs . No differences between patient groups were observed for mean (±standard deviation [SD]) 1‐hour CCI (11.4 [±4.9] for PR‐PLT vs. 11.0 [±4.9] for controls), mean (±SD) 24‐hour CCI (6.1 [±4.4] for PR‐PLTs vs. 6.2 [±4.8] for controls), and for the other evaluated outcomes. No differences between PC types were observed for mean (±SD) 1‐hour CCI (10.6 [±6.7] for PR‐PLTs vs. 9.9 [±6.2] for conventional PCs ) and mean 24 hour‐ CCI (3.3 [±3.9] for PR‐PLTs vs. 4.2 [±5] for conventional PCs ). Thirty‐five percent of PR‐PLTs and 38% of conventional PCs (p = 0.63) were associated with 1‐hour CCI s of less than 7.5. Inadequate 24‐hour CCIs were observed for 72% of PR‐PLTs and 64% of conventional PCs (p = 0.002). Conclusions Transfusion efficacy of single‐donor apheresis PCs in PAS treated with amotosalen PR versus gamma irradiation is comparable.