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The effect of frequent whole blood donation on ferritin, hepcidin, and subclinical atherosclerosis
Author(s) -
Peffer Karlijn,
Heijer Martin,
Holewijn Suzanne,
Graaf Jacqueline,
Swinkels Dorine W.,
Verbeek André L.M.,
Atsma Femke
Publication year - 2013
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2012.03916.x
Subject(s) - hepcidin , subclinical infection , ferritin , medicine , blood donor , iron status , immunology , anemia , iron deficiency
Background Iron catalyzes the formation of free radicals, which could lead to damaged vascular walls and subsequent atherosclerosis. Blood donation decreases iron stores and can thus decrease cardiovascular risk. Even within blood donors, differences in stored iron are observed. This study investigates whether increasing lifetime number of donations decreases the extent of subclinical atherosclerosis within blood donors. Study design and methods Subclinical atherosclerosis was evaluated in 269 blood donors by measuring intima–media thickness (IMT), pulse‐wave velocity (PWV), and ankle–brachial index (ABI). Lifetime number of whole blood donations was categorized into sex‐specific donation tertiles. Results Ferritin and hepcidin were lower in high‐frequency donors compared to low‐frequency donors. Donors in the third sex‐specific donation tertile had on average a 0.3% (95% confidence interval [CI], −3.6 to +3.0%) lower IMT, a 2.1% (95% CI, −3.9 to +8.0%) higher PWV, and a 1.5% (95% CI, −1.4 to +4.5%) higher ABI compared to donors in the first sex‐specific donation tertile. Conclusion With such small differences and no consistent trend across donation groups, it cannot be concluded that blood donation has a beneficial effect on the extent of subclinical atherosclerosis.