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Cellular therapies supplement: the role of granulocyte macrophage colony‐stimulating factor and dendritic cells in regulatory T‐cell homeostasis and expansion
Author(s) -
Zou Tao,
Satake Atsushi,
Ojha Priti,
Kambayashi Taku
Publication year - 2011
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2011.03379.x
Subject(s) - granulocyte macrophage colony stimulating factor , microbiology and biotechnology , biology , regulatory t cell , immunology , homeostasis , macrophage , cytokine , dendritic cell , t cell , immune system , il 2 receptor , in vitro , biochemistry
Regulatory T cells are a subset of T cells with inhibitory function that are critical for protection against autoimmunity and immunopathology. A failure to maintain adequate regulatory T‐cell numbers in the periphery results in autoimmune manifestations, highlighting the importance of the continuous maintenance of peripheral regulatory T cells. The cellular and molecular requirements for regulatory T‐cell homeostasis and expansion are not fully understood but involve a complex interplay among dendritic cells, conventional T cells, and regulatory T cells. In addition, soluble factors such as the cytokine granulocyte macrophage colony‐stimulating factor may play a role in enhancing these interactions. In this review, we discuss our National Blood Foundation‐funded studies relating to the role of granulocyte macrophage colony‐stimulating factor and dendritic cells in controlling regulatory T‐cell homeostasis and expansion.