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Hemolytic transfusion reaction due to anti‐IH
Author(s) -
Irani Mehraboon S.,
Richards Cheryl
Publication year - 2011
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2011.03209.x
Subject(s) - medicine , hemolysis , hemoglobinuria , coombs test , hemolytic anemia , antibody , serology , immunology , anemia , gastroenterology
BACKGROUND: Anti‐IH is usually a clinically insignificant antibody that may complicate a serologic workup. However, it can occasionally cause hemolysis. We report a rare case of acute hemolysis caused by anti‐IH. CASE REPORT: A 60‐year‐old man with a long history of chronic myelomonocytic leukemia and anemia, blood group A, D+ was found to have an unidentified antibody on serologic workup. He received an A, D+ red blood cell (RBC) unit that was crossmatch compatible by immunoglobulin G indirect antiglobulin test and then experienced an acute hemolytic transfusion reaction with fever, hemoglobinuria, and acute renal failure. The antibody was later identified as an anti‐IH with a wide thermal amplitude. The transfused RBCs were later typed as A 2 . The patient was subsequently typed as an A 1 individual. The patient recovered completely from the effects of this reaction and was transfused with A 1 RBCs over the next few days with no adverse effect. CONCLUSION: Anti‐IH, which is usually clinically insignificant and often found in A 1 , B, and A 1 B individuals, can, on rare occasions, cause acute hemolytic transfusion reactions, especially when an A 2 unit is transfused to an A 1 patient.