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A mild acute hemolytic transfusion reaction in a patient with alloanti‐Ge3: a case report and review of the literature
Author(s) -
Baughn Mariah R.,
Whitacre Patricia,
Lo Grace S.,
Pandey Suchitra,
Lane Thomas A.
Publication year - 2011
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2011.03093.x
Subject(s) - medicine , antibody , transfusion reaction , premedication , red blood cell , reactivity (psychology) , coombs test , immunology , anesthesia , pathology , alternative medicine
BACKGROUND: The clinical significance of the Gerbich antibodies has been described as variable and there are no well‐documented reports of hemolytic transfusion reactions (HTRs). CASE REPORT: We present the case of a woman with a long history of documented anti‐Ge3 alloantibody who received multiple units of Ge+ red blood cells (RBCs) uneventfully. During the first admission to our hospital she was transfused 8 units of Ge+ RBCs and had a negative monocyte monolayer assay (MMA) before receiving the units. Within 2 weeks of the transfusions, the anti‐Ge3 became significantly stronger by indirect antiglobulin test, and the MMA increased from 2.2 to 79.5% reactivity. She returned 4.5 years later with an emergent need for blood and was transfused with 2 units of Ge+ RBCs after premedication with steroids and intravenous immunoglobulin. RESULTS: The first unit was transfused without incident; however, she developed clinical and laboratory signs consistent with an acute HTR with the second unit. CONCLUSION: After a comprehensive review of the literature, we believe this to be the first well‐documented case of acute HTR due to anti‐Gerbich alloantibodies.