Premium
Neonatal alloimmune neutropenia due to immunoglobulin G antibodies against human neutrophil antigen‐5a
Author(s) -
Porcelijn Leendert,
Abbink Floor,
Terraneo Loes,
Hoogen Laura Onderwatervd,
Huiskes Elly,
de Haas Masja
Publication year - 2011
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2010.02858.x
Subject(s) - antibody , immunology , neutropenia , antigen , antiserum , granulocyte , isoantibodies , monoclonal antibody , medicine , neonatal alloimmune thrombocytopenia , biology , pregnancy , fetus , genetics , toxicity
BACKGROUND: Neonatal alloimmune‐mediated neutropenia (NAIN) due to maternal alloantibodies directed against one of the human neutrophil antigens (HNAs) can cause severe infections. NAIN has been described as caused by antibodies against HNA‐1a, ‐b, ‐c, ‐2a, ‐3a, or ‐4a, but not by antibodies against HNA‐5a. RESULTS: Blood from a 3‐week‐old newborn and from his parents was sent to our laboratory because of suspicion of NAIN. Granulocyte‐specific antibodies were present in the maternal antiserum and reactive with the paternal granulocytes. The specificity of the maternal alloantibodies was shown to be anti‐HNA‐5a by the monoclonal antibody immobilization of granulocyte antigens assay. The mother was genotyped HNA‐5a negative, and the father was genotyped homozygous HNA‐5a positive. CONCLUSION: We identified a first case of NAIN due to maternal alloantibodies against HNA‐5a.