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Female donors and transfusion‐related acute lung injury
Author(s) -
Middelburg Rutger A.,
Van Stein Daniëlle,
Zupanska Barbara,
Uhrynowska Małgorzata,
Gajic Ognjen,
MuñizDiaz Eduardo,
Galvez Nuria Nogués,
Silliman Christopher C.,
Krusius Tom,
Wallis Jonathan P.,
Vandenbroucke Jan P.,
Briët Ernest,
Van Der Bom Johanna G.
Publication year - 2010
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2010.02715.x
Subject(s) - medicine , transfusion related acute lung injury , confidence interval , relative risk , serology , blood transfusion , lung , immunology , pulmonary edema , antibody
BACKGROUND: Although quantitative evidence is lacking, it is generally believed that the majority of cases of transfusion‐related acute lung injury (TRALI) are caused by female blood donors. We aimed to examine the relation between female donors and the occurrence of TRALI. STUDY DESIGN AND METHODS: We performed an international, multicenter case‐referent study. TRALI patients who were diagnosed clinically, independent of serology or donor sex, and had received transfusions either only from male donors or only from female donors (unisex cases) were selected. The observed sex distribution among the donors of these TRALI patients was compared to the expected sex distribution, based on the relevant donor populations. RESULTS: Eighty‐three clinical TRALI cases were included; 67 cases received only red blood cells (RBCs), 13 only plasma‐rich products, and three both. Among RBC recipients the relative risk (RR) of TRALI after a transfusion from a female donor was 1.2 (95% confidence interval [CI], 0.69‐2.1) and among plasma‐rich product recipients the RR was 19 (95% CI, 1.9‐191). The p value for the difference between RBCs and plasma was 0.023. CONCLUSION: Our data support the notion that plasma from female donors is associated with an increased risk of TRALI, while RBCs from female donors are not.