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Scrub typhus induced by peripheral blood stem cell transplantation in the immunocompromised patient: diagnostic usefulness of nested polymerase chain reaction
Author(s) -
Kang SeungJi,
Park KyungHwa,
Jung SookIn,
Jang Hee Chang,
Ji Soo Young,
Ahn Jae Sook,
Kim Hyeoung Joon,
Shin JongHee,
Kim Dong Min
Publication year - 2010
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2009.02442.x
Subject(s) - scrub typhus , nested polymerase chain reaction , polymerase chain reaction , medicine , orientia tsutsugamushi , immunology , virology , rickettsiosis , transmission (telecommunications) , biology , antibody , gene , serology , biochemistry , electrical engineering , engineering
Scrub typhus ( Orientia tsutsugamushi ) is a Gram‐negative rickettsial disease in parts of Asia, transmitted from wild rodents to human by mites. This is a case report of scrub typhus contraction in an acute leukemia patient by transfusion of peripheral blood stem cells collected during the incubation period. Although human‐to‐human transmission of scrub typhus by needle‐stick injury or transplacental transmission has previously been reported, this is the first case confirmed by polymerase chain reaction (PCR) and DNA sequencing. This type of incident shows the need to heighten awareness of the threat of rickettsial agents in transfused blood. Nested PCR is a useful diagnostic method to confirm the diagnosis during incubation period and in the early phase of disease, especially for immunocompromised patients.