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TRANSFUSION COMPLICATIONS: Bacterial contamination of pediatric whole blood transfusions in a Kenyan hospital
Author(s) -
Hassall Oliver,
Maitland Kathryn,
Pole Lewa,
Mwarumba Salim,
Denje Douglas,
Wambua Kongo,
Lowe Brett,
Parry Christopher,
Mandaliya Kishor,
Bates Imelda
Publication year - 2009
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2009.02344.x
Subject(s) - medicine , kenya , contamination , blood transfusion , intensive care medicine , transfusion reaction , whole blood , emergency medicine , pediatrics , surgery , ecology , biology , political science , law
BACKGROUND: Hospitalized children in sub‐Saharan Africa frequently receive whole blood transfusions for severe anemia. The risk from bacterial contamination of blood for transfusion in sub‐Saharan Africa is not known. This study assessed the frequency of bacterial contamination of pediatric whole blood transfusions at a referral hospital in Kenya. STUDY DESIGN AND METHODS: This was an observational study. Over the course of 1 year, bacteriologic cultures were performed on 434 of the 799 blood packs issued to children by the blood bank of Coast Provincial General Hospital, Mombasa. Clinical outcome was not assessed. RESULTS: Forty‐four bacterial contaminants were isolated from 38 blood packs—an overall contamination frequency of 8.8% (95% confidence interval, 6.1%‐11.4%). Sixty‐four percent of the bacteria isolated were Gram‐negative. Many of the isolates are usually found in the environment and the most likely source of contamination was considered to be the hospital blood bank. CONCLUSION: Bacterial contamination of whole blood may be a significant but unrecognized hazard of blood transfusion for children in sub‐Saharan Africa. Further work is needed to clarify the extent of the problem and its clinical consequences. Increased awareness and adherence to basic principles of asepsis in the hospital blood bank may be important immediate interventions.