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Efficacy in reducing potassium load in irradiated red cell bags with a potassium adsorption filter
Author(s) -
Cid Joan,
Ramiro Laia,
Bertran Sílvia,
Martínez Núria,
Claparols Montse,
Maymó Rosa Ma,
Puig Lluís,
Pla Ramon Pau
Publication year - 2008
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2008.01776.x
Subject(s) - potassium , adsorption , chemistry , organic chemistry
BACKGROUND: The transfusion of red cell (RBC) bags with high amounts of potassium (K + ) causes concern about an increased risk of cardiac arrest because of transient hyperkalemia. To prevent K + overload, a K + adsorption filter (PAF) is available for use at bedside. The aim of the present study was to analyze the efficacy in reducing K + load in irradiated RBC bags with this PAF. STUDY DESIGN AND METHODS: Whole‐blood (WB) bags were collected from volunteer donors on Day 0. RBC bags were prepared from WB bags on Day +1 and stored at 2 to 6°C. RBC bags were irradiated on Day +14 and filtered with the PAF on Day +28, according to the manufacturers' instructions. The plasma electrolyte levels (Na + , K + , Cl ‐ , Ca 2+ , and Mg 2+ ) were measured at the different points during storage. RESULTS: Twelve RBC bags were prepared with a final volume of 274 ± 15 mL. On Day +28, the volume of RBC bags was 257 ± 15 mL, and the PAF was used at a flow rate of 4 ± 0.7 mL per minute. K + level after RBC bag preparation was 1.28 ± 0.59 mmol per L. The K + level was 60.6 ± 2.68 mmol per L on Day +28, just before filtration with the PAF. After filtration, the level of K + was 3.42 ± 2.91 mmol per L. CONCLUSION: This study has shown a high efficacy in reducing potassium load in irradiated RBC bags with the use of the PAF.