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Maternal human platelet antigen‐1a antibody level correlates with the platelet count in the newborns: a retrospective study
Author(s) -
Killie Mette Kjær,
Husebekk Anne,
Kaplan Cecile,
Taaning Ellen,
Skogen Bjørn
Publication year - 2007
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2007.01063.x
Subject(s) - neonatal alloimmune thrombocytopenia , medicine , platelet , immunology , antibody , antigen , retrospective cohort study , pregnancy , obstetrics , fetus , biology , genetics
BACKGROUND: Maternal plasma and/or serum levels of anti‐HPA‐1a at delivery were compared to neonatal platelet (PLT) counts. STUDY DESIGN AND METHODS: Samples from HPA‐1bb women who gave birth to children with thrombocytopenia or had anamnestic information about a previous child with neonatal alloimmune thrombocytopenia (NAIT) were collected at delivery. A modified monoclonal antibody immobilization of PLT antigen method was used for quantification of anti‐HPA‐1a. RESULTS: The anti‐HPA‐1a level in women with severely thrombocytopenic children was higher than the corresponding level in mothers of children born with moderate thrombocytopenia or normal PLT counts. CONCLUSION: Our data show a significant correlation between maternal anti‐HPA‐1a level and the neonatal PLT count and indicate strongly that this may be a reliable predictive measure for NAIT. Suitable test systems for quantitative measurements of anti‐HPA‐1a must be developed and evaluated for this particular purpose.