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Prospective comparison of high‐dose plateletpheresis with the latest apheresis systems on the same donors
Author(s) -
Picker Susanne Maria,
Radojska Stela Marinova,
Gathof Birgit Sybille
Publication year - 2006
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2006.00928.x
Subject(s) - plateletpheresis , apheresis , medicine , blood donor , nuclear medicine , platelet , immunology
BACKGROUND: To improve productivity of automated platelet (PLT) collection, the industry has introduced new instruments or modifications to existing equipment. STUDY DESIGN AND METHODS: With the same 8 donors for double (DDC) and triple‐dose PLT collection (TDC), the Baxter Amicus (AM), the Haemonetics MCS Plus (MCS+), and the Gambro Trima Accel (TA) were evaluated focusing on yield, duration, and citrate donor load. Target endpoints were set at 5.5 × 10 11 to 6.0 × 10 11 PLTs (DDC) and 7.5 × 10 11 to 8.0 × 10 11 PLTs (TDC) in up to 100 and 120 minutes’ donation time, respectively. RESULTS: TA was the most efficient system (74.5 ± 3.9%) with significant differences from AM (71.1 ± 3.9%; p = 0.028) and MCS+ (64.0 ± 7.7%; p = 0.002). TA had advantages over AM for collection rate (10.9 × 10 9 ± 2.2 × 10 9 vs. 10.1 × 10 9 ± 1.5 × 10 9 PLTs/min; p = 0.382), whole blood processed (3928 ± 611 mL vs. 4219 ± 727 mL; p = 0.382), and time to obtain an established standard dose (TSD 2.5 EU , 30.2 ± 5.6 vs. 37.7 ± 5.5 min; TSD 3.5 US , 42.2 ± 7.8 min vs. 52.7 ± 7.7 min; p = 0.015), whereas AM was slightly superior in PLT yield (2.81 × 10 11 ± 0.21 × 10 11 vs. 2.76 × 10 11 ± 0.31 × 10 11 /unit; p = 0.645). Owing to the lowest draw (42.3 ± 3.2 mL/min; p < 0.001) and collection rates (6.0 × 10 11 ± 1.5 × 10 11 /min; p = 0.021), MCS+ was the slowest significantly (p < 0.001) but compensated with fewer citrate reactions owing to lower citrate infusion rates (0.78 ± 0.11 mL/min/L; p = 0.028). CONCLUSION: High‐dose plateletpheresis was performed efficiently and safely with all three instruments. AM had advantages in PLT yield, and MCS+, in donor comfort. TA was the fastest in obtaining an established standard dose and, because of this advantage, the machine with the highest practical impact in routine use.