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Transient respiratory disturbance by granulocyte–colony‐stimulating factor administration in healthy donors of allogeneic peripheral blood progenitor cell transplantation
Author(s) -
Yoshida Isao,
Matsuo Keitaro,
Teshima Takanori,
Hashimoto Daigo,
Tanimoto Yasushi,
Harada Mine,
Tanimoto Mitsune
Publication year - 2006
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2006.00700.x
Subject(s) - medicine , granulocyte colony stimulating factor , white blood cell , respiratory system , progenitor cell , transplantation , granulocyte , gastroenterology , anesthesia , immunology , stem cell , chemotherapy , biology , genetics
BACKGROUND: Allogeneic peripheral blood progenitor cell (PBPC) transplantation requires granulocyte–colony‐stimulating factor (G‐CSF) administration to mobilize PBPCs in healthy donors. The effects of G‐CSF on pulmonary functions, however, have not been clearly elucidated in PBPC donors. STUDY DESIGN AND METHODS: Respiratory status by measurements of arterial blood gas was prospectively evaluated serially in 25 healthy donors (9 men, 16 women; age, 18‐61 years) administered a dose of 10 µg per kg for 5 days. RESULTS: White blood cell (WBC) counts increased in all the subjects after G‐CSF administration; means on Days 0, 3, and 5 were 6 × 10 9 , 33.4 × 10 9 , and 33.6 × 10 9 per L, respectively. The mean PaO 2 values on the respective days were 93.1, 85.8, and 81.8 mmHg, and these changes were significant (p < 0.0001), remaining significant after adjustment for the WBC count. Levels of both PaCO 2 and AaDO 2 were significantly higher after G‐CSF administration than those before G‐CSF administration (p < 0.0001 and p = 0.0004, respectively). SaO 2 was significantly decreased after G‐CSF administration (p = 0.0002). Age was identified as a significant predictive factor for the increase of AaDO 2 and PaO 2 decline. These observations clearly indicate that the gas exchange was significantly affected during G‐CSF administration in healthy PBPC donors. CONCLUSION: Considering an increasing use of PBPC mobilization by G‐CSF, careful monitoring of the respiratory status is important to ensure safety of PBPC donors, especially elderly donors.