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A single dose of 6 or 12 mg of pegfilgrastim for peripheral blood progenitor cell mobilization results in similar yields of CD34+ progenitors in patients with multiple myeloma
Author(s) -
Bruns Ingmar,
Steidl Ulrich,
Kronenwett Ralf,
Fenk Roland,
Graef Thorsten,
Rohr UlrichPeter,
Neumann Frank,
Fischer Johannes,
Scheid Christof,
Hübel Kai,
Haas Rainer,
Kobbe Guido
Publication year - 2006
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2006.00699.x
Subject(s) - pegfilgrastim , medicine , filgrastim , apheresis , progenitor cell , granulocyte colony stimulating factor , cd34 , multiple myeloma , urology , chemotherapy , gastroenterology , stem cell , platelet , biology , genetics
BACKGROUND: Current regimens for peripheral blood progenitor cell (PBPC) mobilization in patients with multiple myeloma are based on daily subcutaneous injections of granulocyte–colony‐stimulating factor (G‐CSF) starting shortly after cytotoxic therapy. Recently a polyethylene glycol–conjugated G‐CSF (pegfilgrastim) was introduced that has a substantially longer t 1/2 than the original formula. STUDY DESIGN AND METHODS: The use of pegfilgrastim was examined at two dose levels for PBPC mobilization in patients with Stage II or III multiple myeloma. Four days after cytotoxic therapy with cyclophosphamide (4 g/m 2 ), a single dose of either 6 mg pegfilgrastim (n = 15) or 12 mg pegfilgrastim (n = 15) or daily doses of 8 µg per kg unconjugated G‐CSF (n = 15) were administered. The number of circulating CD34+ cells was determined during white blood cell (WBC) recovery, and PBPC harvesting was performed by large‐volume apheresis. RESULTS: Pegfilgrastim was equally potent at 6 and 12 mg with regard to mobilization and yield of CD34+ cells. No dose dependence was observed because CD34+ cell concentration peaks were 131 and 85 per µL, respectively, and CD34+ cell yield was 10.2 × 10 6 and 7.4 × 10 6 per kg of body weight, respectively. Pegfilgrastim in either dose was associated with a more rapid WBC recovery (p = 0.03) and an earlier performance of the first apheresis procedure (p < 0.05) in comparison to unconjugated G‐CSF. No difference regarding CD34+ cell maximum and yield could be observed. CONCLUSION: A single dose of 6 mg pegfilgrastim is equally potent as 12 mg for mobilization and harvest of PBPCs in patients with multiple myeloma. Because no dose dependency was seen at these dose levels, this might be also true for even smaller doses.