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Porcine red blood cells express a polyagglutinable red blood cell phenotype
Author(s) -
Swanson Jane L.,
Cooling Laura
Publication year - 2005
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2005.00462.x
Subject(s) - medicine , citation , library science , family medicine , computer science
The shortage of human blood and organs has led to increased interest in animal substitutes. In both transplantation and transfusion, the greatest roadblock to the use of animal tissues is the expression of xenoantigens. A major xenoantigen in pigs is linear B (Gal α 1-3Gal β 14GlcNAc-R), a cross-reactive, B-like antigen expressed on red blood cells (RBCs) and other tissues that is recognized by naturally occurring antibodies present in human serum. 1,2