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The influence of blood group differences in allogeneic hematopoietic peripheral blood progenitor cell transplantation
Author(s) -
Erker Christian G.,
Steins Martin B.,
Fischer RudolfJosef,
Kienast Joachim,
Berdel Wolfgang E.,
Sibrowski Walter,
Cassens Uwe
Publication year - 2005
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2005.00214.x
Subject(s) - abo blood group system , medicine , conditioning regimen , transplantation , pure red cell aplasia , hemolysis , blood transfusion , progenitor cell , hematopoietic stem cell transplantation , hematology , immunology , gastroenterology , oncology , stem cell , anemia , biology , genetics
BACKGROUND: Severe immunohematologic complications after ABO‐mismatched allogeneic blood peripheral blood progenitor cell (PBPC) transplantation (PBPCT), including pure red cell aplasia and immune hemolysis, have been described. Although several studies have addressed this issue, the clinical influence of blood group differences on transfusion requirements and survival is still discussed controversially, especially in the case of PBPCT. STUDY DESIGN AND METHODS: This single‐center study is based on 143 patients receiving PBPCT after standard or reduced‐intensity conditioning. The influence of blood group differences in the ABO, Rh, and Kell systems on red blood cell, platelet, and plasma transfusion requirements; length of hospitalization in transplantation unit; survival; and occurrence of graft‐versus‐host disease was investigated. Additionally, the influence of the conditioning regimen and irregular antibodies on the measures mentioned above was analyzed. RESULTS: Multivariate analysis demonstrated that minor and bidirectional ABO mismatch (p = 0.028) and Rh difference (p = 0.020) independently led to poorer survival. The Kell difference did not show significant influences on the measures mentioned above. A clinically relevant influence of blood group differences on transfusion requirements could not be demonstrated. Irregular antibodies also did not show significant influences. CONCLUSION: These findings indicate an influence of blood group differences in PBPCT on survival and must be studied in further detail.