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Human platelet antigen systems in allogeneic peripheral blood progenitor cell transplantation: effect of human platelet antigen mismatch on platelet engraftment and graft‐versus‐host disease
Author(s) -
GarcíaMalo M.D.,
Corral J.,
González M.,
Solano C.,
GonzálezConejero R.,
Caballero M.D.,
Pérez R.,
Moraleda J.M.,
Vicente V.
Publication year - 2004
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.2004.03190.x
Subject(s) - immunology , medicine , human leukocyte antigen , antigen , graft versus host disease , platelet , immune system , transplantation , progenitor cell , stem cell , biology , genetics
BACKGROUND: Alloimmune incompatibility in allo‐geneic stem cell transplantation (ASCT), pregnancy, and blood transfusion might trigger an immune response with clinical consequences. Human PLT antigens (HPAs), which play a significant role in pregnancy or blood transfusion‐associated alloimmune thrombocytopenia, are also expressed on the surface of tissues affected by GVHD. Thus, HPA mismatch in HLA‐identical ASCT could play a potential role in PLT engraftment and GVHD. STUDY DESIGN AND METHODS: We studied the HPA‐1, ‐2, and ‐5 genotypes in Caucasian donors and patients involved in 77 HLA‐identical ASCTs. We evaluated the association of HPA compatibility with clinical outcome, analyzing the relevance of host‐versus‐donor HPA incompatibility in PLT engraftment and donor‐versus‐host HPA incompatibility in GVHD. RESULTS: PLT engraftment and transfusion require‐ments were similar in HPA‐compatible and HPA‐incompatible ASCT. Cases with severe thrombocytopenia or significant delayed PLT engraftment did not display host‐versus‐donor HPA incompatibility. Moreover, the incidence of GVHD did not correlate with HPA compatibility. CONCLUSION: Our results support no role for these antigens in immune complications of ASCT: PLT engraftment, requirement of PLT transfusions, and GVHD.