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An Evaluation of Antiglobulin Control Cells: Inability to Detect Errors in the Antiglobulin Test
Author(s) -
Wenz B.,
Dugan E. P.
Publication year - 1978
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1978.tb02973.x
Subject(s) - hemagglutination , immunology , hemagglutination assay , bovine serum albumin , hemagglutination tests , human albumin , antibody , chemistry , virology , medicine , albumin , titer
Hemagglutination of antiglobulin control cells from several manufacturers, as well as cells sensitized in our own laboratory, was demonstrated in the presence of bovine albumin, normal human serum, and neutralized anti‐human serum. Macroscopic hemagglutination was inconsistently enhanced by the addition of active anti‐human serum. This protean reactivity of the reagent cells invalidates any conclusion derived from a positive antiglobulin control.