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The Effect of Cryoprecipitate Volume on Factor VIII Content
Author(s) -
Bettigole R. E.,
Tourbaf K.,
Robson E. B.,
Schultz M.
Publication year - 1974
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1974.tb04586.x
Subject(s) - cryoprecipitate , volume (thermodynamics) , medicine , chemistry , physics , fibrinogen , quantum mechanics
Two hundred and thirty‐five cryoprecipitates were sampled and assayed for Factor VIII activity. Two hundred and twenty‐five of these were given to 11 patients with hemophilia on 53 occasions. The patients' Factor VIII levels were measured just before and 15 minutes after infusion. The rise in Factor VIII activity averaged 97 per cent of the expected rise calculated from the cryoprecipitate assays and plasma volume estimates. The mean Factor VIII content per bag of cryoprecipitate was 61 units. There is a highly significant probability that the smallest volume cryoprecipitates had significantly less Factor VIII than average and that the largest volume cryoprecipitates had significantly more Factor VIII than the average.