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Another Example of Human Chimerism
Author(s) -
Carr E. O.,
McDonald L. A.
Publication year - 1974
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1974.tb04564.x
Subject(s) - buccal swab , typing , biology , population , abo blood group system , andrology , lymphocyte , red cell , immunology , red blood cell , genetics , microbiology and biotechnology , medicine , environmental health
Routine blood typing demonstrated two populations of red blood cells in a dizygotic female twin. Approximately 30 per cent of the red blood cells are A 1 B, MS/Ns, cde/cde and 70 per cent are O/O, Ns/Ns, CD u e/cde. Red blood cell typing and secretor tests on the family showed the minor population to be the true genetic cell line of the propositus. Further evidence of chimerism is revealed by the presence of both XX and XY karyotypes. Tissue cultures showed only XX, lymphocyte cultures only XY, and buccal smears were chromatin positive. There was no evidence of two populations of white blood cells by leukocyte antigen typing. Comparative studies of the male twin were impossible because of his death three months prior to this discovery; however, he was reported by the Armed Services to the AB, Rh negative and we presume he had a mixture of A 1 B and O cells and that he was genetically group O.