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Increased Granulocyte Collection with the Blood Cell Separator and the Addition of Etiocholanolone and Hydroxyethyl Starch
Author(s) -
McCredie K. B.,
Freireich E. J.,
Hester J. P.,
Vallejos C.
Publication year - 1974
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1974.tb04545.x
Subject(s) - leukapheresis , hydroxyethyl starch , etiocholanolone , extracorporeal circulation , medicine , adverse effect , granulocyte , chemistry , surgery , anesthesia , androsterone , biology , steroid , genetics , stem cell , cd34 , hormone
A total of 201 leukaphereses have been performed on 73 donors to collect granulocytes for transfusion to infected leukopenic recipients. The pretreatment of the donor with etiocholanolone and the addition of hydroxyethyl starch to the extracorporeal circulation significantly increased the total number of granulocytes collected. Adverse side effects were minimal. The majority of donors underwent the procedure on 13 occasions over a period of eight weeks. Follow‐up donors two or more years later has revealed no long‐term adverse side effects from leukapheresis or from the addition of etiocholanolone and hydroxyethyl starch.