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Evidence for Two Anomalous I Blood Group Determinants
Author(s) -
McGinniss M. H.,
Grindon A. J.,
Schmidt P. J.
Publication year - 1974
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1974.tb04527.x
Subject(s) - immunology , antigen , hemagglutinin (influenza) , medicine , biology , chemistry
One normal donor has been found whose red blood cells type as I positive with all anti‐I sera except those obtained from patients with chronic cold hemagglutinin disease (CCHD). In addition, these cells had more H than other random O cells and may be devoid of i antigen. Complete absorption of non‐CCHD anti‐I with the unusual cells left an anti‐I reactive with other I positive cells. These unique cells have allowed definition of at least two separate I determinants present on adult cells.