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Combined Maternal Erythrocyte Autosensitization and Materno‐Fetal Jk a Incompatibility
Author(s) -
Dorner I.,
Moore J. A.,
Chaplin H.
Publication year - 1974
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1974.tb04520.x
Subject(s) - pregnancy , titer , abo blood group system , fetus , cord blood , medicine , umbilical cord , obstetrics , immunology , physiology , antibody , biology , genetics
A black woman in the second month of her fourth pregnancy was found to have moderately strong autosensitization of her own erythrocytes (RBC) by C3d (α2D); at the same time, anti‐Jk a was detected in her serum. At term she delivered a healthy Jk a ‐positive ABO‐compatible infant whose RBC were very strongly coated by C3d. Anti‐Jk a was demonstrable in maternal and cord serum at a titer of 1/64, and in an eluate from the newborn infant's washed RBC at a titer of 1/8. Despite very strong RBC C3d sensitization and the persistence of free anti‐Jk a in the infant's circulation for at least six weeks postpartum, no evidence for hemolytic disease of the newborn developed. The infant's benign course is discussed in relation to 16 reports of maternofetal Kidd isosensitization in pregnancy.