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Complement‐Fixing Antibodies to the AD‐169 Strain of Cytomegalovirus in Banked Blood
Author(s) -
Monif G. R. G.,
Adams W. R.,
Flory L. F.
Publication year - 1974
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1974.tb04485.x
Subject(s) - cytomegalovirus , antibody , economic shortage , titer , medicine , incidence (geometry) , immunology , blood transfusion , population , complement (music) , virology , blood units , biology , virus , viral disease , herpesviridae , phenotype , linguistics , philosophy , physics , biochemistry , environmental health , complementation , government (linguistics) , optics , gene
One thousand consecutive units of blood, on which donor data could be obtained, were titered for the presence of complement‐fixing (CF) antibodies to the AD‐169 strain of cytomegalovirus. Twenty‐one per cent of the units had a positive titer at a significant level. Blood obtained through commercial sources had a distinctly higher incidence of specific antibody than that obtained from a predominantly student population. Because of the high incidence of CF antibodies to the cytomegaloviruses, a decision to exclude blood from use in transfusion would seriously affect the already critical blood shortage. However, the fact that use of such blood for transfusion is associated with significant danger (especially in certain critical patient populations) makes it important that further studies be carried out to provide the data necessary for a wise decision.