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The High Incidence of Anti‐HL‐A Antibodies in Anti‐D Typing Reagents. Illustrated by a Case of Matuhasi‐Ogata Phenomenon Mimicking a “D with Anti‐D” Situation
Author(s) -
Wilkinson S. L.,
Vaithianathan T.,
Issitt P. D.
Publication year - 1974
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1974.tb04480.x
Subject(s) - serology , antibody , typing , antigen , incidence (geometry) , phenomenon , immunology , medicine , virology , biology , genetics , mathematics , philosophy , epistemology , geometry
On rare occasions persons are found whose red blood cells react as D‐positive yet have anti‐D present in their serum. The usual explanation of this finding is that the red blood cells lack a portion of the D antigen mosaic and the individual has formed anti‐D directed against the missing portions of the mosaic. This paper presents details of a case that closely resembled this situation but in which it was eventually possible to prove that misleading serological results had been obtained because of the Matuhasi‐Ogata phenomenon. The specific antigen‐antibody complex responsible for the Matuhasi‐Ogata phenomenon in this case was Bg b ‐anti‐Bg h . Investigation of a large number of anti‐D typing sera revealed the presence of anti‐Bg (anti‐HL‐A) antibodies in nearly 50 per cent of them. The implications of these findings are discussed.