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Six Additional Examples of Anti‐At a
Author(s) -
Gellerman M. M.,
McCreary J.,
Yedinak E.,
Stroup M.
Publication year - 1973
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1973.tb05479.x
Subject(s) - antibody , hemolytic disease of the newborn (abo) , antigen , immunology , medicine , allele , phenotype , haemolytic disease , disease , pediatrics , genetics , biology , gene , pregnancy , fetus
Six additional examples of anti‐At a are reported. Four of the antibodies studied prior to the publication of the original anti‐Ata (Mrs. August.) were known to be identical to each other but the antibody had never been assigned a name. Besides the propositi, three additional At(a—) people have been found among the siblings. The propositi in these six families as well as that of the original report are Negroes indicating the At(a—) phenotype to be a predominantly Negro characteristic. The characteristics of the sera indicate the antibodies are IgG but there is no clinical evidence that they caused hemolytic disease of the newborn. Many additional antigens of high frequency have been excluded from being the same as At a . Further information excluding the possible allelic relationship of At a to known factors of low frequency has been obtained.