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Autoimmune Hemolytic Anemia Caused by Anti‐D
Author(s) -
Adams J.,
Moore V. K.,
Issitt P. D.
Publication year - 1973
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1973.tb05476.x
Subject(s) - autoimmune hemolytic anemia , antibody , immunology , hemolytic anemia , anemia , coombs test , autoimmune disease , medicine , phenotype , biology , gene , genetics
A case of autoimmune hemolytic anemia of the “warm” antibody type is described. The patient is of Rh Phenotype D+, C+, E‐, c‐, e+ for a probable Rh genotype of R 1 R 1 . During the first 19 weeks of the course of the study, his serum and eluates made from his red blood cells were found to contain a potent, autoreactive, anti‐D and, at times, a second, weaker antibody. The second antibody reacted with all test cells available except Rh null . At the end of the eight‐month period of study, the eluate was found to be nonreactive with Rh null and LW‐negative cells. Apparently as the autoimmune disease progressed, the specificity of the causative antibody changed.